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Oral Qualifying Exam on Biomaterials
Study References
1.Biomaterials Science: An Introduction to Materials in Medicine 2nd Edition, Ratner (ed), Academic Press, 2000.
2.Essential Cell Biology: An Introduction to the Molecular Biology of the Cell, Alberts et. al. (eds.), Garland Publishing, 1998.
3. Essentials of Human Anatomy & Physiology, Marieb, Addison Wesley Longman, 2000.
4. Molecular Biology of the Cell, by B. Alberts, et al., 4th edition, 2002. An authoritative textbook for introductory cell biology and molecular biology. Familiarity with the content in chapters 1-3 is highly recommended.
5 . Intermolecular and Surface Forces, by J. Israelachvili, 1986, Academic Press. A classic textbook on aspects of complex fluids and colloid science relevant to biology
Topics
Structure and function of mammalian cells (basic)
Human anatomy and physiology (basic)
Surface properties of materials and characterization methods (intermediate)
Protein and cell interactions with surfaces (intermediate)
Inflammatory and immunological reactions to implanted materials (intermediate)
Biocompatibility testing of materials (intermediate)
In vitro test methods to predict in vivo performance (intermediate)
Bioceramics - examples, structure/properties, applications, limitations (advanced)
Biometals - examples, structure/properties, applications, limitations (advanced)
Biopolyers - examples, structure/properties, applications, limitations (advanced)
Medical device design processes (intermediate)
FDA regulation of medical devices and product liability law (basic)
Drug and gene delivery from biomaterials (intermediate)
Tissue engineering of hard and soft tissue and organs (intermediate)
Animal models for biomaterials and medical device testing (intermediate)
Nano- and microscale devices (intermediate) MATSE 401, 420, 441.
Fundamental interactions in biological systems (ionic, van der Waals, H-bonding networks, hydrophobic interactions, Structural (solvation, steric, hydration) interactions, polymer-mediated interactions, etc.)
Structure of water
Membrane structure and function
Mechanics of membranes DNA structure and relation to function
Mechanics of stiff polymers
Basic protein structural motifs
Knowledge of recent developments in field